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Real-world Multiple Myeloma Patient Experience by Frailty Status: Symptom Burden, Physical Function, Quality of Life, and Treatment Bother Captured from Electronic Patient-Reported Outcomes (ePROs)

By May 13, 2024No Comments
Poster: Real-world Multiple Myeloma Patient Experience by Frailty Status: Symptom Burden, Physical Function, Quality of Life, and Treatment Bother Captured from Electronic Patient-Reported Outcomes (ePROs)

Authors: Nicholas C. Coombs PhD MSTAT1, Emily R. Beamon, PhD MA MPH1, Emelly Rusli MPH2, Debra Wujcik PhD RN2, Aaron Galaznik MD MBA2, Omer Jamy MD3

1 Piedmont Research Strategies , Greensboro, NC, 2 Carevive Systems, Inc., Boston, MA, 3 University of Alabama at Birmingham, Birmingham, AL

Background

  • Evidence suggests the value of frailty status when deciding on treatments in Multiple Myeloma (MM) practice 1,2.
  • Electronic Patient-Reported Outcomes (ePROs) enable the capture of patient experience related to frailty and outcomes.
  • This study aimed to explore symptom burden, physical function, quality of life, and treatment bother collected from ePROs by frailty status.

Methods

  • Patients with MM were enrolled in Carevive PROmpt®, a remote symptom monitoring platform, between 9/1/2020 and 3/10/2023.
  • Baseline frailty status was ascertained from Carevive’s modified Geriatric Assessment (mGA), the Cancer and Aging Resilience Evaluation (CARE) geriatric survey, and patient-reported functional status (PRFS).
  • Outcomes were described using the validated tools: derived PROCTCAE for symptoms, PROMIS 4a Physical Function for physical function, global health/QoL items from EORTC QLQ-C30 for quality of life, and a single item FACT GP5 for treatment bother.
  • Results were stratified by frailty status (Fit, Intermediate, Frail).

Conclusion

  • Over the course of treatment, MM patients reported more treatment burden, better physical function and QoL, and more treatment bother.
  • Findings suggest there may be functional differences in the overall patient experience at different levels of frailty in MM.
  • This further underscores the importance of capturing frailty status in oncology care.
Poster: Real-world Multiple Myeloma Patient Experience by Frailty Status: Symptom Burden, Physical Function, Quality of Life, and Treatment Bother Captured from Electronic Patient-Reported Outcomes (ePROs)

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