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Real-World Pain Symptom Trajectory Among Multiple Myeloma Patients Under Remote Symptom Monitoring With Electronic Patient-Reported Outcomes (ePRO)

By May 18, 2023May 23rd, 2023No Comments
Poster: Real-World Pain Symptom Trajectory Among Multiple Myeloma Patients Under Remote Symptom Monitoring With Electronic Patient-Reported Outcomes (ePRO)

Authors: Nicholas C. Coombs, PhD, MSTAT1 , Emily R. Beamon, PhD, MA, MPH1 , Emelly Rusli, MPH2, Debra Wujcik, PhD2, Aaron Galaznik, MD2, and Tanya M. Wildes, MD, MSCI3
1 Piedmont Research Strategies
2 Carevive Systems, Inc.
3 University of Nebraska Medical Center

Objectives

Multiple Myeloma (MM) is a cancer where patients often experience pain due to osteolytic lesions. Many patients receive treatment long-term, and symptom burden and quality of life are important to consider for patient well-being. In this study, we used electronic patient-reported outcomes (ePRO) through a remote symptom monitoring program in MM patients experiencing variable levels of pain

Methods

  • MM patients over age 18 currently on treatment were enrolled in the Carevive PROmpt® remote symptom monitoring program from March 1, 2021 to October 30, 2022.
  • All patients received baseline and weekly surveys assessing domains across symptom burden, physical function, frailty status, and overall health indicators.
  • Fourteen unique symptoms were assessed using items derived from the Patient-Reported Outcomes Version of the Common Technology Criteria
    for Adverse Events (PRO-CTCAE). Patients were followed through 16 weeks.

Results

  • A total of 49 patients were included in analysis.
  • For these patients, the average number of symptoms reported was 4.5, compared to 2.1 for those without baseline pain.
  • Both those with and without baseline pain experienced a reduction in average number
    of symptoms over time.
  • They were primarily male (63%) and White (80%) with a mean age of 68.6.
  • Nearly one-third of patients (n=13) reported baseline pain, which was severe in four cases.
  • However, those with baseline pain, on average, experienced at least one other co-occurring symptom throughout follow-up.

Conclusions

This study highlights the importance of monitoring and addressing pain in MM patients, as pain at baseline may be associated with a higher symptom burden during treatment. This study also demonstrates the feasibility of ePROs and remote symptom monitoring in real-world clinical practice for assessing symptom burden and monitoring patient quality of life.

 

Poster: Real-World Pain Symptom Trajectory Among Multiple Myeloma Patients Under Remote Symptom Monitoring With Electronic Patient-Reported Outcomes (ePRO)

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